The Supplementary Materials Audit
MethodologyComments
If we are auditing the ledger, does the suggested method for checking n-counts specifically account for these 'exploratory' subgroups, or do those usually slip through the cracks?
But what about when the outlier removal is pre-specified in the study protocol... does that change the weight we give to those discarded points...?
The shift toward open science and preregistered reports makes these audits much more powerful. We can now compare the final supplementary data against the original analysis plan.
Preregistration is a start, but it often misses post-hoc subgroup analyses. These are usually tucked away in the supplement as 'exploratory' results to avoid admitting the primary hypothesis failed.
Preregistration is fine for the authors, but it doesn't capture the reality of the lab bench. The people actually running the assays are usually the first to notice the data drift before it gets cleaned for the appendix.